| # | Rider | Team | Time | Gap |
|---|---|---|---|---|
| 1 | Paolo Bettini | Quick Step | 06:06:22 | |
| 2 | Fränk Schleck | Team CSC | + 02:57 | + 02:57 |
| 3 | Lorenzo Bernucci | Fassa Bortolo | + 02:57 | + 02:57 |
| 4 | Danilo Di Luca | Liquigas - Bianchi | + 03:10 | + 03:10 |
| 5 | Samuel Sánchez | Euskaltel-Euskadi | + 03:10 | + 03:10 |
| 6 | Steffen Wesemann | T-Mobile Team | + 03:35 | + 03:35 |
| 7 | Heinrich Haussler | Gerolsteiner | + 03:39 | + 03:39 |
| 8 | Thomas Löfkvist | Française des Jeux | + 03:41 | + 03:41 |
| 9 | Mirko Celestino | Domina Vacanze | + 03:57 | + 03:57 |
| 10 | Vladimir Miholjevic | Liquigas - Bianchi | + 03:57 | + 03:57 |
| 11 | Gregory Rast | Phonak Hearing Systems | + 04:37 | + 04:37 |
| 12 | Sylvain Chavanel | Cofidis | + 04:59 | + 04:59 |
| 13 | Andrea Moletta | Gerolsteiner | + 06:43 | + 06:43 |
| 14 | Damiano Cunego | Lampre-Caffita | + 07:08 | + 07:08 |
| 15 | Andriy Grivko | Domina Vacanze | + 07:08 | + 07:08 |
| 16 | Martin Elmiger | Phonak Hearing Systems | + 07:08 | + 07:08 |
| 17 | Giampaolo Caruso | Liberty Seguros - Würth Team | + 07:08 | + 07:08 |
| 18 | Leonardo Bertagnolli | Cofidis | + 07:08 | + 07:08 |
| 19 | Carlos Barredo | Liberty Seguros - Würth Team | + 07:11 | + 07:11 |
| 20 | Alejandro Valverde | Illes Balears - Caisse d'Epargne | + 07:11 | + 07:11 |
| 21 | Carlos Sastre | Team CSC | + 07:11 | + 07:11 |
| 22 | Alessandro Bertolini | Domina Vacanze | + 08:38 | + 08:38 |
| 23 | Markus Zberg | Gerolsteiner | + 08:40 | + 08:40 |
| 24 | Pablo Lastras | Illes Balears - Caisse d'Epargne | + 08:40 | + 08:40 |
| 25 | Gorazd Stangelj | Lampre-Caffita | + 08:40 | + 08:40 |
| 26 | Bram de Groot | Rabobank | + 08:40 | + 08:40 |
| 27 | Luis Rubiera José | Discovery Channel | + 08:40 | + 08:40 |
| 28 | Michael Barry | Discovery Channel | + 08:40 | + 08:40 |
| 29 | Rubens Bertogliati | Saunier Duval - Prodir | + 08:40 | + 08:40 |
| 30 | Michael Albasini | Liquigas - Bianchi | + 08:40 | + 08:40 |
| 31 | Fabian Cancellara | Fassa Bortolo | + 08:40 | + 08:40 |
| 32 | Michele Scarponi | Liberty Seguros - Würth Team | + 08:40 | + 08:40 |
| 33 | Patrik Sinkewitz | Quick Step | + 08:40 | + 08:40 |
| 34 | Rik Verbrugghe | Quick Step | + 08:40 | + 08:40 |
| 35 | Pieter Weening | Rabobank | + 08:40 | + 08:40 |
| 36 | Vicente García José | Illes Balears - Caisse d'Epargne | + 18:04 | + 18:04 |
| 37 | Laurent Brochard | Bouygues Telecom | + 24:25 | + 24:25 |
| 38 | Aurelien Clerc | Phonak Hearing Systems | + 24:25 | + 24:25 |
| 39 | Chris Horner | Saunier Duval - Prodir | + 24:25 | + 24:25 |
| 40 | Steve Zamperi | Phonak Hearing Systems | + 24:25 | + 24:25 |
| 41 | Grischa Niermann | Rabobank | + 24:25 | + 24:25 |
| 42 | Benoît Poilvet | Crédit Agricole | + 24:25 | + 24:25 |
| 43 | Amaël Moinard | Cofidis | + 24:25 | + 24:25 |
| 44 | Philip Deignan | AG2R Prévoyance | + 24:25 | + 24:25 |
| 45 | Uros Murn | Phonak Hearing Systems | + 24:25 | + 24:25 |
| 46 | Yannick Talabardon | Crédit Agricole | + 24:25 | + 24:25 |
| 47 | Christian Vande Velde | Team CSC | + 24:25 | + 24:25 |
| 48 | Stéphane Goubert | AG2R Prévoyance | + 24:25 | + 24:25 |
| 49 | Francesco Bellotti | Crédit Agricole | + 24:25 | + 24:25 |